[Brutal] Women gain sexual pleasure from the pain that is inflicted upon them.

PPEcel

PPEcel

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Their default posture towards 80% of men is contempt; they are secure in their absurd conviction that they are superior to most men.
You even see foids starting physical fights with men shorter than they are because they feel physically dominant, which isn't the case.
 
Aedracel

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Number of particles in the Universe IQ.

Foids get turned ON by pain, that is why they get attracted to violent and Dark triad Chads so much.

Even a coalburner got so many pairs of mudshark sunglasses, she will still stick to the Tyrone who gave her.
 
Koruga

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TY. You're a fast reader.



This thread is exactly as high IQ and long as it has to be.
I worked three months on this.
Wow, I thought that for these things, you would only need to spend a few hours looking for information that aligns with your thesis.
 
epillepsy

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Wow, I thought that for these things, you would only need to spend a few hours looking for information that aligns with your thesis.
well i didn't work on it for three months straight, doing nothing else.
i also had to do other things.
i really hated working on this thread and got distracted a lot.
 
Kevin Logan

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I archived the articles just in case

Do men and women feel pain differently?

Course Update for Nurse Anesthetists Gender Differences in Pain : Does X = Y ?

Ouch! Why Women Feel More Pain

Gender differences in pain ratings and pupil reactions to painful pressure stimuli

Angelina Jolie reveals her dark sexual exploits

This is the best way to give a woman an orgasm, apparently

The Riddle of the Sphincter

We Spoke to Size Queens About Why They Prefer Big Dicks

Pain drug reveals what most already know - men's and women's brains are simply different

Reward Processing by the Opioid System in the Brain

Reward Processing by the Opioid System in the Brain

Gender and the Pain Experience

Gender Differences In Brain Response To Pain

Gender Differences in Traditional Chinese Medicine Use among Adults in Taiwan
 
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Aedracel

Aedracel

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I archived the articles just in case














Based
 
Koruga

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well i didn't work on it for three months straight, doing nothing else.
i also had to do other things.
i really hated working on this thread and got distracted a lot.
Well, I finished reading the thread, I had not read something so well constructed for a long time, and as a bonus your post gives a new paradigm in the way of seeing the human being and especially women. Your post reminded me of this:
48e25d78f49301cbcffe3631d31f06a8d4642c5d32947aeef11659aadc6ad254.jpg


Great minds think the same.
 
your personality

your personality

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IMPORTANT INFORMATION

1. Introduction

View attachment 363735

Joan of Arc at the Coronation of Charles VII (1854), Jean Auguste Dominque Ingres.

Joan of Arc (1412-31) was an historical foid who lived during the Hundred Years’ War, a great conflict between France and England.

Born in the peaceful French village of Domrémy, Joan suffered from schizophrenic delusions since early childhood. At the age 17, she hallucinated that an evil spirit was instructing her to lead France’s army to victory over the English. She was so insistent about this that she was granted an audience with the royal court. Upon hearing her prophecy, the imbecilic King of France, Dauphin Charles VII, took her at her word and placed her in command of a battalion of soldiers.

Joan’s first military campaigns were successful. In 1429, Joan and her soldiers relieved the besieged French at the Siege of Orleans, earning her the title of “The Maid of Orleans.” In May, 1430, however, her fortunes changed dramatically and she was routed and captured by the English in Compiègne. After a short trial, she was sentenced to death by burning at for the crime of witchcraft.

Thousands of people witnessed Joan’s execution, and many accounts of her death survive to this day. As she burned at the stake, the following signs were observed:

1. Her muscles contracted and tensed up.
2. Her breasts became full and began to heave violently.
3. She cast her eyes up to heaven, and her expression was not one of pain, but something approaching spiritual ecstasy.
4, In the instant before she lost consciousness, Joan moaned out Jesus’s name three times, loud enough to be heard over the roar of the flames.
5. Joan’s vagina, in contrast to the dry kindling that burned around her, became lubricated and wet.

View attachment 363741

Individually, each of these signs do not point to a clear conclusion. But taken together, they indicate an undeniable certainty: as the flames enfolded and consumed her body, Joan of Arc was caught within the grips of a powerful orgasm.


2. Masochism

Masochism is defined as “the condition of experiencing recurring and intense sexual arousal in response to enduring moderate or extreme pain, suffering, or humiliation.” It’s described as an addiction-like tendency, with features resembling drug addiction: craving, intoxication, tolerance, and withdrawal.

Masochism is seen as aberrant in males and treated as a harmful psychological disorder.

Female masochism, on the other hand, does not suffer from the same stigma, given its ubiquity.



Confirming this, In Three Essays on the Theory of Sexuality (1924), Sigmund Freud described the three essential traits of femininity -- narcissism, passivity, and masochism. To Freud, pain was an inseparable part of the intensity of a woman’s sexual pleasure, “an expression of the feminine being nature.” He found in women a persistent need for punishment and humiliation, "which succeed [...] in binding erotically the destructive trends which have been diverted inwards."

There are numerous examples of masochism in females:

A. Women overwhelmingly prefer larger-than-average penises.

Here are some quotes from a VICE article:




The top selling dildos on the internet are eight to nine inches long. In the absence of a large cock, some women resort to bestiality with dogs and horses, animals with large cocks.

However, a penis of this size inflicts injuries and perforations on the vagina and causes lasting damage in the form of tears in the cervix, as well as dilation of the vaginal opening. Infections can occur, and there are several case reports of pelvic abscess and subsequent scarring due to insertion of large objects into the vagina.

B. Women love anal sex, despite the lack of an erogenous zone there.

Homosexual men also engage in anal sex. But keep in mind that gay men have erogenous zones deep within their ani known as prostate glands. Women lack this, and so in theory anal sex should be not pleasurable for them, and instead extremely painful. Nevertheless, women engage in sodomy for pastime.





Repeated anal sex (especially with the oversized penises women prefer) can harm the sphincter and rectum, leading to rectal prolapse and leakage/loose stools.

C. One reason women seek out and stay with attractive abusive men because they enjoy being beaten up.

Women seek out abusive (attractive) partners and stay with men who regularly beat them. In addition to psychological reasons, this is because the pain of getting physically assaulted turns them on. In fact, many women report having had the best sex of their lives immediately following such an “abusive episode.”

Studies on this phenomenon are suppressed and hidden by Google’s search algorithm.

D. Women engage in various paraphilias, including “knife play.”

Angelina Jolie reported that she could not reach orgasm during sex without being cut with a knife.


Here, the actress is referring to a variation of “knife play,” a common fetish among women in which a sharp knife is inserted carefully into the vagina, causing targeted lacerations in the walls of the cervix and sending waves of sexual pleasure surging through the woman’s body.

***

In each of the above examples, harmful stimuli that should be perceived as dysphoric are misinterpreted by the female brain as euphoric; women feel pain as pleasure, even when their bodies are placed at harm’s risk.

From this, we can conclude there is a maladaptive mechanism in the female brain whereby pain is transformed into its polar opposite pleasure. Psychological aspects to this masochism exist as well, but the basis of this pleasure is neurological.

3. Counterpoint

Despite this, many studies deny the existence of this innate masochism in females, some even claiming that women suffer more pain than men.

Here is one such study:

In this study, an equal number of men and women were exposed to painful electrical stimuli of controlled strength.
Pupillary dilation was measured in both groups, and each participant was asked to rate on a decile scale how much pain they felt.

The female group presented with more pupillary dilation than the male group, and rated their pain higher than the men did. From this, the researchers concluded that women felt more pain than men.

But there are two obvious flaws with this methodology.

First, measuring pupillary dilation to quantify perceived pain is unreliable, since pupils dilate in response to both pain and pleasure. The dilation itself does not signify that specifically pain or pleasure is being felt, only that one of the two are. Naturally, the researchers assumed that the pupils dilated due to pain, but logically, pleasure cannot be ruled out.

Pupils also dilate in response to any strong emotion.

The second, and more detrimental, flaw was in asking the subjects to rate their pain themselves.

As researchers at UCLA (Toomey, et al) pointed out:


Asking subjects to rate their own pain runs into the same problem as the studies that compare the number of sex partners between men and women. In that case, men exaggerated their true number, while women minimized theirs. Here, we can be sure that the opposite will be the case. Women will pretend to feel great pain because of hypochondria and victim complex, whereas men will attempt to appear masculine by deliberately minimizing the amount of pain they feel.

Because of these flaws in methodology, the only valid conclusion we can derive from this study is that, when it comes to injury, women complain more than men.

***

A second argument is that women feel more pain than men due to having more nerves.


This argument also fails to convince.

Since my thesis is that pain is felt as pleasure to women, the more nerves a person has, the more able she is to feel not only pain, but also the concomitant pleasure. Increased nerve density increases potentiality of pleasure as well as pain. And if during a given pain event the pleasure overcrowds the pain, that intermingled feeling can’t be said to be pain at all, but pleasure, mathematically speaking. In a linear sense, pain you want to repeat over and over again due to the pleasure you get from it can’t be called pain. It's similar to the pleasure of repeatedly scratching a mosquito bite or bearing down on an aching tooth.


4. The Perception of Pain as Pleasure (In Women)

[...] that peak of sensitivity where the scarlet and the white threads of ultimate pain and ultimate joy are woven together...
- Yukio Mishima, Runaway Horses

I. Men experience pain in the analytical regions of the brain, whereas women experience “pain” in the emotional regions.

In 2008, researchers at UCLA conducted a study focusing on gender differences in pain perception:


Here, researchers applied heat stimulations to the forearms of an equal number of male and female volunteers, while monitoring their brains using positron emission tomography (PET) scans.
The PET scans measured increases in blood flow and cerebral activation patterns during pain perception.

After analyzing the results, they concluded that “the cognitive, or analytic, region of the male brain lights up, while the female limbic system, the brain's emotional headquarters, springs into action.”


Specifically, males had a larger magnitude of opioid receptor activation in the following areas:
1. Anterior thalamus
2. Hypothalamus
3. Ventral basal ganglia

While females had far more opioid receptor activation in the limbic system, comprised of:
1. Amygdala
2. Hypocampus
3. Thalamus

As in the previous study, the researchers noted that “the females verbally perceived the 50°C heat stimulus as more intense compared with males.”

The authors speculated that, because pain causes an emotionally charged limbic response in women, that may be responsible for the greater
complaining from the women. In other words, women felt “offended” by this pain, as if it were a social faux pas, and reacted similarly to it as if they had been hurt psychologically, rather than physically.

The authors assimilated this difference with greater activation in the thalamus, anterior insula, and contralateral prefrontal cortex of females as evidenced by the PET scan. The difference found within the prefrontal cortex may be responsible for the affective, or psychological, differences seen between genders in pain perception.

Even a foid scientist agrees:




According to Graham, nociceptive pain sensed in the limbic system (as it is in women) cannot be differentiated from psychological pain when examined through current medical technology.

Thus, increased activity in the limbic system in response to physical pain stimuli does not necessarily indicate a felt non-psychological pain.
This further suggests that, for women (but not men), physical pain is almost indistinguishable from social, psychological pain, such as being excluded, offended, outraged, or sad.

A woman, unable to distinguish between emotional and physical pain except through first causes, evidently wouldn’t be able to understand the distinction, no more than a blind man can comprehend the concept of vision.


II. Pain response is “mu-dominant” in females, while it is “kappa-dominant” in males.

When a nerve ending detects a painful stimulus, it sends a signal to the central nervous system, where the body produces calming and pain-relieving hormones called endorphins.

Endorphins (contracted from endogenous morphine) are a opioid-like substance similar to fentanyl that reduces pain in response to painful stimuli. Endorphins are “caught” by different opioid receptors in various parts of the brain, and produce varying effects depending on the type of opioid receptor they are caught by.

There are three different types of opioid receptors: mu, kappa, and delta.
Mu and kappas are the two most significant receptors; delta receptors have minimal effect in alleviating nociceptive pain.
Binding sites for the three receptors overlap in many brain structures, but some structures exhibit higher expression of one receptor over the others.

Here are some “brain maps” that show where mu- and kappa-opioid receptors are found in the brain.

View attachment 363763



As you can see, mu-opioid receptors are more prevalent in the limbic system, whereas kappa-opioid receptors predominate in the cognitive centers of the brain.

Specifically:
Mu is the most expressed opioid receptor in the amygdala, thalamus, mesencephalon and some brain stem nuclei. (1)
In a few structures, only one receptor type is detected: mu binding sites only are detected in four thalamic nuclei (lateral geniculate thalamus, ventrolateral thalamus, ventromedial thalamus, and posterior thalamus), the sensory trigeminal nucleus (SNT) and nucleus ambiguus (Amb).

Kappa is the most represented receptor in the basal anterior forebrain, including the claustrum (Cl) and endopiriform cortex (En), olfactory tubercle (Tu), striatum (caudate putamen and nucleus accumbens), preoptic area (POA), hypothalamus, and pituitary.
Kappa binding sites only are found in seven brain regions that are part of the stress axis (Cl, paraventricular hypothalamus, arcuate nucleus, supraoptic nucleus, Me, CeA, and pituitary).

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482114/

A Yale study similarly found mu-opioid dominance in females and kappa-receptor dominance in males.

Males had significantly higher V T and thus a higher KOR (kappa opioid receptor) availability than women in multiple brain regions.

Mu-opioid dominance is also confirmed by better reaction from females to mu-opioid-specific drugs than men. Women required 40% less morphine (a mu-opioid-specific medicine) than men for post-operative, reardless of body weight or diffusion of the drug in the body.
Women also seem to get much greater pain relief from mixed-action opioid medications and experience greater pain relief with mu-specific opioids.
Based on these findings, researchers concluded that that mu-opioid receptor (MOR) binding density would be higher in females than in males.


In addition, the idea that males and females respond differently to opioids is not new, but until recently the difference was believed to be limited to potency, with clinical studies showing that women require less morphine for post-operative pain than men.
(4) Research by Craft found that women use 40% less opioid-based medicine than men for postoperative pain.10 This finding was confirmed by Miaskowski et al in an analysis of 18 studies of postoperative opioid use.
Several studies of pain after oral surgery revealed that women get much greater pain relief from mixed-action opioid medications (eg, pentazocine, nalbuphine, butorphanol).12 More recently, a meta-analysis of this literature confirmed that women seem to experience greater pain relief with opioids.
In their study, the researchers also discovered that female rats received significantly more pain relief when mu opioid was injected into the vlPAG than male rats, a fact that was not attributable to body weight or diffusion of the drug in the body.
***
Moreover, men are more likely than women to engage in substance abuse (Lynch et al. 2002), while women become addicted to opiates more quickly following first use (Lex 1991; Roth et al. 2004). Similarly, female rats acquired heroin self-administration more quickly than their male counterparts, and subsequently, self-administered larger amounts of the drug (Lynch and Carroll 1999; Cicero et al. 2003). It is plausible that sex differences in MOR activation underlie sex differences in these behaviors. In support, PET scan studies revealed higher MOR binding in several brain regions of women compared to men (Zubieta et al. 1999). Likewise, higher MOR binding density was found in several brain regions in female rats compared to males, although these rats were gonadectomized (Vathy et al. 2003). However, it remains unknown whether sex differences are present in the intact rat brain and whether these sex differences emerge early in development. Therefore, our second aim was to compare MOR binding density between intact male and female rats at both juvenile and adult ages. Based on these previous findings in humans and gonadectomized adult rats (Zubieta et al. 1999; Vathy et al. 2003), we hypothesized that MOR binding density would be higher in females than in males.

III. Mu are the rewarding receptors, while kappa are the punishing receptors.

Mu and kappa receptors both serve a role in mediating nociceptive pain, but do so in different ways. To put it simply, mu-opioid receptors “reward” pain, whereas kappa receptors “punish” it.

The functional response of mu- and kappa-opioid receptors can be replicated through the administration of mu-specific or kappa-specific drugs. The pain response of opioid receptors can be emulated to a greater or lesser extent by administering these drugs and observing their effects.
In other words, the effects caused by theses receptor-specific agonists are the same (differering only in degree) as the “natural” response to pain caused by non-artificial means of activation (i.e. actual pain stimuli, rather than induced activation).


A. Mu Receptors

The areas in which mu-opioid receptors are most prevalent (the limbic system, the primary regions in which females register pain) are known informally as “hedonistic hotspots.” These areas of the brain play a large role in the reinforcement of pleasure. Overactivation of this area are drug addiction, food addiction, etc.
These receptors contribute to the reinforcing properties of most drugs of abuse.
Stimulation of mu opioid receptors generates an increase in both “liking” and “wanting” for reward.
Thus, mu-opioid receptors induce relaxation, trust, satisfaction and have a strong analgesic effect.

Morphine is a powerful pain relieving drug that produces euphoria. It is mu-opioid specific, meaning it acts on and targets the mu-opioid receptors. Other mu-specific drugs include heroin and fentanyl. Most opioid drugs of abuse fall under this category.
The effects of morphine include euphoria, mood lift, relaxation, and analgesia.


Relevant to drug intake, genetic data demonstrate that mu receptors contribute to the reinforcing properties of most drugs of abuse, [...]
The opioid system, which mediates hedonic evaluation of natural rewards, represents another key substrate for the deleterious effects of drugs of abuse. Indeed, the reinforcing properties of many abused drugs depend on the activation of mu opioid receptors
which thus may be a potential molecular gateway to drug addiction (72).
Conversely, mu and delta antagonists [medications which inhibit the effect of these receptors] suppress the positive reinforcing properties of natural rewards and opiate or nonopioid drugs, whereas kappa receptors induce dysphoria and counteract mu receptors in regulating hedonic homeostasis. (2)
SOURCE: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482114/

B. Kappa Receptors

Kappa is generally known to be a dysphoric, aversive receptor in terms of its pain-mediating effects.

While systemic mu agonists (morphine, heroin, etc) produce positive reinforcement, kappa agonists induce aversion, hallucinations, and malaise, producing anxiety, fear, and depression.
Furthermore, activation of kappa receptors counteract the reward processes of the mu-receptors, and in male models, increases psychological discomfort associated with pain.

Because of these dysphoric effects, no kappa-specific drug is in wide use today, either as anaesthesia or recreationally. Mixed-action opioids, however, such as nalbuphine, have been used on women to some success, although they are ineffective in men (See Section IV).

Kappa receptors are the “punishing” receptors.
It is believed that kappa-opioid receptors exist to produce avoidance behaviors in response to pain, causing extreme negative feelings to be associated with the source of the pain, so that the brain can learn to avoid similar sources of pain in the future.

Pharmacological studies have long shown that kappa receptor activation is aversive in animal models.
Globally systemic mu agonists produce positive reinforcement, whereas kappa agonists induce aversion, hallucinations, and malaise.
Kappa receptors also counteract reward processes under stressful conditions.

Traditionally, kappa-opioids have been dismissed as ineffective analgesics in humans.
Nalbuphine, which is often used to anesthetize women during childbirth, does little to mitigate pain in men.

Kappa receptors induce dysphoria and counteract mu receptors in regulating hedonic homeostasis. (2)
SOURCE: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482114/

KOR agonists produce signs of anxiety, fear, and depression in laboratory animals and humans, findings that have led to the hypothesis that drug withdrawal-induced DYN release is instrumental in negative reinforcement processes that drive addiction. However, these studies were almost exclusively conducted in males.

***

In short, MOR (mu-opioid receptors) produce a euphoric effect in response to pain, similar to that of fentanyl, heroin, or morphine.
KOR (kappa-opioid receptors), however, produce a dysphoric effect, causes psychological discomfort, anxiety, fear, and depression.

IV. Kappa receptors work synergistically with mu receptors in females, increasing the “rewarding” effect. In contrast, the two receptors work at cross purposes in males; kappa decreases the effect of mu receptors in men, thereby increasing the “punishing” effect.

In Section III, it has been established that kappa receptors are punishing and dysphoric. New studies have suggested, however, that the negative effects of KOR activation seems to only be present in males. In females, kappa receptor activation appears to have a synergistic effect with mu-opioid receptors, making the “rewarding” aspects of it more powerful.

Because kappa-opioids had mostly been tested on male subjects, on whom kappa activation results in dysophoria and great mental distress, medical professionals traditionally have dismissed kappa-opioids as viable analgesics in humans.

However, UCSF scientists recently performed a study about the analgesic effects of kappa agonists, this time on human female subjects.
They undertook this after a previous study discovered that kappa-opioids brought pain relief to female rats but not male rats.

They found that in women, a drug made up of a strong concentration of kappa-opioid has a strong and lasting analgesic effect.
In contrast, in men, the low dose actually increased pain; as the dose was increased, the heightened pain disappeared and a weak, short-lived analgesic effect set in.

In their previous study on rats, the Fields team showed that treating the vlPAG neurons of male rats with a mu opioid brought about pain relief, but that subsequently adding kappa-opioid into the RVM markedly decreased the mu opioid’s analgesic effect.
In males, KOR worked to sabotage MOR in a sense, and decreased the rewards of mu.

However, Treating the vlPAG neurons of female rats with a mu opioid brought on the expected pain relief, but subsequently adding kappa-opioid into the RVM increased the mu opioid’s analgesic effect.

Traditionally, kappa-opioids have been dismissed as ineffective analgesics in humans.
While the majority of sex difference findings related to KOR are from studies of the analgesic effects of kappa agonists, there is also emerging evidence of KOR-related sex differences in addictive and affective states [6].
This led them to reexamine the posibility of using kappa-opioids as analgesics, only in human females.
Researchers led by UCSF scientists are reporting that an experimental pain drug known as a kappa-opioid brings pain relief to female rats but not males, a finding that adds weight to a recent UCSF clinical finding, and highlights, they say, the need to evaluate drugs by gender.
Fields’ finding-that specific brain regions in male and female rats have opposite reactions to kappa-opioids, supporting clinical studies at UCSF that indicate kappa-opioids are more effective in women for clinically significant pain.
A clinical study led by UCSF professor Jon Levine, MD, PhD showed that, in women, a drug made up of a strong concentration of kappa-opioid has a strong and lasting analgesic effect.
In contrast, in men, the low dose actually increased pain; as the dose was increased, the heightened pain disappeared and a weak, short-lived analgesic effect set in.
The discovery, he says, demonstrates a clear biological difference in the way women and men respond to kappa-opioids.
Three years ago, the Fields team showed that treating the vlPAG neurons of male rats with a mu opioid brought about pain relief, but that subsequently adding kappa-opioid into the RVM markedly decreased the mu opioid’s analgesic effect.
Treating the vlPAG neurons of female rats with a mu opioid brought on the expected pain relief, but subsequently adding kappa-opioid into the RVM increased the mu opioid’s analgesic effect.
“In males, kappa-opioid is somehow inhibiting the actions of mu-opioid,” says Fields.
Kappa receptors are acting on opposite types of neurons in males and females. In males, kappas may be inhibiting the so-called “off” nerve cells in the RVM that normally tell the spinal cord to shut off pain signals. In females, kappa-opioids actually excite the off neurons, which would relieve pain.


In men, however:
The functionality of kappa- and delta-opioid receptors, might be less associated with relaxation and analgesic effects as kappa-OR often suppress activation of mu-opioid receptors, and delta-OR differ from mu-OR in its interaction with agonists and antagonists.

What these studies show is that mu- and kappa-opioid receptors work at cross-purposes in males, decreasing the rewarding effects of mu receptors.
However, the two receptors work synergistically in females; kappa activation increases the rewarding effects of mu receptors.

V. Estrogen is a natural painkiller that modulates opioid receptors to be more effective.

Estrogen is present in women at a level that is 10 to 15 times higher than the level present in men.

In 2011, researchers (Stenning et al) discovered that estrogen can modulate the density of opioid receptors.

Estrogen have also been found to induce mu-opioid receptor activation within the preoptic nucleus and posterodorsal medial amygdaloid nucleus.

High densities of estrogen receptors functionally related to endorphin receptors have been found within the hypothalamus, one of the primary sites of MOR. [mu-opioid receptors]

In addition, research on sex hormones indicates there is improved mu receptor binding in some brain regions in women after they receive estrogen, as measured by PET scans.
One of the conclusions forwarded from this research is that a decrease in estrogen would increase sensitivity to pain. Conversely, an increase in estrogen would promote analgesic effect by stimulating a bolus of pain-inhibiting transmitters.

The effects of estrogen modulation of pain receptors is further confirmed in a study by Dr. Kern Olson.
According to him:
Girls and boys react to pain in a similar fashion before puberty but differently after puberty; these differences, however, decrease as levels of sex hormones decrease as people age. (i.e., after menopause, when estrogen levels in women plummet)


Aside from their function in reproduction, sex hormones and their receptors that are widely distributed throughout the central nervous system have
demonstrated modulatory effects on the central opioid system to responses in pain.

Estrogen have also been found to induce mu-opioid receptor activation within the preoptic nucleus and posterodorsal medial amygdaloid nucleus.

High densities of estrogen receptors functionally related to endorphin receptors have been found within the hypothalamus, an area
with a high density of neuroendocrine and centrally projecting neurons.
(Toomey et al)
29 This effect can be blocked by the mu-opioid antagonist naltrexone,
29 which further demonstrates these hormoneopioid receptor interrelationships.
In addition, research on sex hormones indicates there is improved mu receptor binding in some brain regions in women after they receive estrogen, as measured by PET scans.
One of the conclusions forwarded from this research is that a decrease in estrogen would increase sensitivity to pain. Conversely, an increase in estrogen would promote analgesic effect by stimulating a bolus of pain-inhibiting transmitters.22



VI. Opioid receptor activation is anti-sexual in men, pro-sexual in women.

According to the same study above:


On a study on rats, an injection of mu-specific opioid drugs into the brains of male rats were seen to suppress male gonadal function. In other words, the rats were unable to maintain an erection after being administered these drugs, and mating behaviors decreased in response.

However, in female rats, administration of mu-specific drugs did not correlate with symptoms of sexual dysfunction.
On the contrary, when mu-opioids were administrated to female rats only in a group, unpaced mating increased. This nymphomania was increased the closer the rats got to estrus, corresponding with higher levels of estrogen. This was associated to higher rates of mu activation, which suggests a certain threshold of pain must be reached before sexual arousal happens.
This suggests that the pro-sexual effect of MOR activation on females will increase when estrogen levels are higher, such as during estrus, certain phases of the menstrual cycle, and the later terms of pregnancy.

The researchers reported that with lower levels of estrogen, progesterone was pronociceptive.
Thresholds were decreased, and pain intensities increased during the midluteal phase when progesterone levels were relatively higher than estrogen levels.

[19] This system is also thought to be important in mediating complex social behaviors involved in the formation of stable, emotionally committed relationships. Social attachment was demonstrated to be mediated by the opioid system through experiments administering morphine and naltrexone, an opioid agonist and antagonist, to juvenile guinea pigs. The agonist decreased the preference of the juvenile to be near the mother and reduced distress vocalization whereas the antagonist had the opposite effects. Experiments were corroborated in dogs, chicks, and rats confirming the evolutionary importance of opioid signaling in these behaviors.
[18] Researchers have also found that systemic naltrexone treatment of female prairie voles during initial exposure to a male reduced subsequent mating bouts and nonsexual socialization with this familiar partner, when a choice test including a novel male was performed afterwards. This points to a role for opioid receptors in mating behaviors.

Stenning et al studied the pain response across the menstrual cycle phases using a cold pressure test. In this study, a demonstration of variations in pain perception that correlate with the fluctuating concentration ratios of estrogen and progesteronewas conducted. The researchers reported that with lower levels of estrogen, progesterone was pronociceptive.
thresholds were decreased, and pain intensities increased during the midluteal phase when progesterone levels were relatively higher than estrogen levels.

Briefly, opioid receptor agonists injected directly into the MPOA inhibited or delayed masculine copulatory activity in rats. Indeed, when injected into this structure, opioid agonists markedly impaired penile erection
Opioids frequently cause low FT levels in men, but there is no relationship between abnormal hormone levels and symptoms of sexual dysfunction. Therefore, all men should be screened for low FT levels. Women on opioids had lower FT levels, but this did not correlate with sexual dysfunction symptoms.

This pro-sexual phenomenon can be observed in human females as well. Estrogen serves to increase the feelings of sexual arousal derived from pain.

This effect can be seen in the “birthgasm.” During pregnancy, the estrogen levels in a women increase the closer she gets to giving birth. This effect is seen during pregnancy and may account for pregnancy-induced increases in tolerance to nociception. This may have evolved so that a woman could better tolerate the “pain” of childbirth. As a result, a woman’s estrogen levels are necessarily highest just before and during the act of giving birth. Estrogen and MOR activation working in tandem have often resulted in women having orgasms during childbirth:

When a woman feels the contractions of an orgasm and/or extreme moments of pleasure right at the moment of delivering her baby, this may be called an “orgasmic birth.” You may feel tremendous pressure and sensation in the vagina as your baby's birth approaches, then a powerful, pleasurable release that's both physical and orgasmic.

This phenomenon is common enough that the term of “birthgasm” was coined.

5. Acupuncture

Acupuncture was a saving grace. It helps more than anything else I tried.
- Molly Qerim, a foid

***

Acupuncture is a form of alternate medicine in which thin needles are inserted into the body. The practice of acupuncture is considered a pseudoscience because the theories and practices of traditional Chinese medicine -- based on the concepts of qu, meridians, and acupuncture points, life force energy -- are not amenable to modern scientific knowledge, and it has been characterized as quackery.
Many scientific reviews have found that acupuncture is ineffective for a wide range of conditions.

Some research results suggest that it can alleviate some forms of pain, though the majority of research suggests that its apparent effects are not caused by the treatment itself. Many acupunctures attribute pain relief to the release of endorphins when needles penetrate.



In other words, there is a prevailing theory that the way acupuncture “works” is by causing pain that causes the body to go into pain control overdrive, releasing endorphins and creating a state of well-being.

Unsurprisingly, the great majority of proponents of acupuncture are female. By some estimates, the ratio of women to men who use acupuncture regularly is 5 to 1. (This especially applies to East Asian women, who are on average more masochistic and exogamic than women of other races.) Discounting the placebo effect, the logical explanation is that acupuncture works for women, but not men.


To see why this is, let’s examine the differences of male and female brains’ reactions in response to acupuncture.

In males:
The needle is inserted.
Pain is sensed by the nerves.
A small number of rewarding mu receptors activate, and a large number of punishing kappa receptors activate.
Mu receptors try to “reward” for the pain. However, the kappa receptors lessen this effect.
Male feels pain and aversion. He begins to associate acupuncture with negative feelings of dysphoria.
The man’s sexual desire decreases, and erection becomes impossible.

In females:
The needle is inserted.
Pain is sensed by the nerves.
A large number of rewarding mu receptors activate, and a small number of synergistically rewarding kappa receptors activate.
Mu rewards the woman for the pain. Kappa helps this effect, transforming pain into pleasure.
Estrogen modulates the pain response, causing sexual arousal.
Female feels euphoria and sexual arousal. She begins to associate acupuncture with positive feelings of euphoria.
The woman’s sexual desire increases; her desire for unpaced mating goes up.

It’s not difficult to see, then, why women are the primary consumers of acupuncture.

***

A famous example of acupuncture working as advertised proves my point further.

In the early 20th century, surgeons performed open heart surgery on a 15-year-old girl in China without using anesthesia. The only measures taken to alleviate the pain of the surgery was acupuncture. Nevertheless, it is said that girl remained calm and immobile during the operation, which was a great success. To this day, this is held up as one of the primary pieces evidence of evidence in support of the efficacy of acupuncture.

However, notice that it was a girl who received the surgery, and not a boy. A male would scarcely have been able to endure the pain of the operation. However, it would have been no difficulty at all for a female.

View attachment 363768


Open heart surgery under acupuncture anaesthesia is depicted on this 8 cent Chinese stamp issued in 1975 as part of a set of four stamps to commemorate the successful integration of traditional Chinese medicine and modern Western medicine in the treatment of various diseases.

The four Chinese characters at right lower corner of the stamp stand for acupuncture anaesthesia. The other three stamps in the set feature such surgical feats as replantation of severed limbs, application of small soft splints for fractures, and cataract surgery.

The patient in this stamp was a 15 year old girl with congenital ventricular septal defect. The Chinese made disc oxygenator for total cardiopulmonary bypass can be seen on the right. The anesthetist who performed the acupuncture-two fine needles inserted in both wrists and a further two in the anterior chest wall at both subclavicular areas-was at the patient's head; he was a practitioner of Chinese traditional medicine. The surgeon on the patient's left was Professor Yi-shan Wang, my schoolmate in St John's University School of Medicine, Shanghhai, China, and the surgeon on the patient's right was Dr Chun-xiu Yeh, my classmate in the same school.


6. Conclusion

Proposed Changes to Society:

1. Medication.
Opioids and anesthetics are inherently dangerous to administer to women, since there is a greater chance of overdose and addiction. (See III.A)
As a result, it would be beneficial for their safety if anesthetics were not administered during female patients’ surgeries.
Anesthesia can be replaced with acupuncture for female patients, which, as shown above (5), has comparable efficacy and far less risk.
This will also increase supply and decrease demand of anesthesia medication, leading to a decrease in the cost of expensive anesthesia procedures.


2. Abortion.
Many current proponents of abortion justify the legality of early-term abortion by the logic that the baby does not yet feel pain.
Following this logic, it would seem that crimes are more serious the more pain is caused.
But women essentially feel no physical pain, as shown above.
To maintain legal consistency, it follows that either abortion must be classed as murder, or crimes that cause bodily injury (battery and domestic assault) to women should not be punished as harshly as those which cause bodily injury to men.

3. Scientific Studies.
German scientists and physicians made great medical advances in the 1940s, due to their progressive genetic research and innovative surgical experimentation, particularly in the area of twins. This was a time of medical enlightenment, and many of the concepts they discovered are still used today. Various legislative considerations, however, prevent us from conducting similar studies today.
However, since our knowledge of the nature of human suffering was then incomplete and now we are more informed, some of these restrictions can now be loosened on experimentation on female subjects.

@ShadowTheEdgehog
@Mainländer
Might go in as record longest OP posted on this forum tbh

I think @soymonkcel would like the part about Kappa versus Mu receptors.

Did you come up with all this while the site was down just hours ago?

I archived the articles just in case

Do men and women feel pain differently?

Course Update for Nurse Anesthetists Gender Differences in Pain : Does X = Y ?

Ouch! Why Women Feel More Pain

Gender differences in pain ratings and pupil reactions to painful pressure stimuli

Angelina Jolie reveals her dark sexual exploits

This is the best way to give a woman an orgasm, apparently

The Riddle of the Sphincter

We Spoke to Size Queens About Why They Prefer Big Dicks

Pain drug reveals what most already know - men's and women's brains are simply different

Reward Processing by the Opioid System in the Brain

Reward Processing by the Opioid System in the Brain

Gender and the Pain Experience

Gender Differences In Brain Response To Pain

Gender Differences in Traditional Chinese Medicine Use among Adults in Taiwan
Based archivecel.
 
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epillepsy

epillepsy

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Did you come up with all this while the site was down just hours ago?
no, of course not.
i've been reading about pain for a while now and constructing the thread for months.
i simply finished the thread last night when i had the time.

there have been longer threads than this, although i can't remember their titles.
 
PersonaDickcel

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fucking brutal

btw, great topic
 
Robtical

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It's also important to note that the pain regulation system that foids have in comparison to men is vastly more effective and the same painful stimuli won't discomfort them even to a fraction of what it does to us.
Yet they are constantly complaining about bee stings, little sprains, etc, and there are gaslighting studies that insist that women feel more pain than men.
It's infuriating.
Yet normie cucks won't care if a foid is beating the shit out of a guy and slapping him, but the moment he hits her once they act like he caused her severe permanent injury. Cucks need to be stomped out.
 
epillepsy

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Yet normie cucks won't care if a foid is beating the shit out of a guy and slapping him, but the moment he hits her once they act like he caused her severe permanent injury. Cucks need to be stomped out.
And foids will assault the man in public, so they have a large supply of white knights to fight on their behalf should the guy retaliate.
I've always dreamed about the perfect opportunity to hit a woman (in self-defense), but cucks won't allow it.

It reminds me of the thread asking why ricecels don't beat noodlewhores when they see WMAF.
Obviously, I can't because I'll be set upon by her white boyfriend and every other man in the region.
 
Robtical

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Also, I have to add that everything you say is true in my own experience.
For example you mentioned later on that in gore videos women seem to be more tough than guys in a weird way.
I can 100% support this, when women get beaten up by guys in these videos, the commenters always note how well they take it.
I remember one where this chinese dude caught his wife cheating and started whipping her with a belt full force and she didnt even flinch.

Based based based, what else can I say?
They should be the ones who fight in wars since they don't care about feeling pain.
 
epillepsy

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They should be the ones who fight in wars since they don't care about feeling pain.
they would desert and run away from every battle.
that's what roastie cops do when they get in a bad situation, there are many videos proving this.
 
Robtical

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And foids will assault the man in public, so they have a large supply of white knights to fight on their behalf should the guy retaliate.
I've always dreamed about the perfect opportunity to hit a woman (in self-defense), but cucks won't allow it.

It reminds me of the thread asking why ricecels don't beat noodlewhores when they see WMAF.
Obviously, I can't because I'll be set upon by her white boyfriend and every other man in the region.
This is why there needs to be more based men around to defend uncucked nonchads from being attacked by whiteknights. Information like this will uncuck many men and soon we will out number the whiteknights in public, so we can be free to hit rosties in self defense. Jfl at whiteknighting for a random rostie because you want to look like "a good man" in front of all the whores in the vicinity. Cringe.
 
radishman

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If only it was true as I can't imagine a more painful experience than fucking a sub8. :feelsmage:
 
Robtical

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they would desert and run away from every battle.
that's what roastie cops do when they get in a bad situation, there are many videos proving this.
Their only use is to serve men so we can develop society, but they don’t even want to do that.
 
MegaSpicCel

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Can I pay you to write my college essays?
 
Numb

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epillepsy

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Can I pay you to write my college essays?
It took me three months to write this.

The New Oxford Essential Guide to Writing by Thomas Kane is a good resource for writing essays.
The section on "Diction" is good.
 
Aedracel

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It took me three months to write this.

The New Oxford Essential Guide to Writing by Thomas Kane is a good resource for writing essays.
The section on "Diction" is good.
IQ mogs me.
 
TheLastSorrow

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They are natural masochists.
 
SkinjobCatastrophe

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Damn thats well put together, dropped an atomic bomb of knowledge on me. Women are nuts, its crazy to learn about them because its like learning about an alpaca. You cant ask an alpaca what they think, you can only measure and observe their behavior so you get a very incomplete and imprecise picture of their behavior and biology. I wonder if we will ever really be able to “know” how women are, in a fundamental sense, or if we are just limited to knowing how they respond to stimuli that we can test directly
 
Appetite4Destrction

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nice thread, bookmarked for l8r.
 
your personality

your personality

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Foids essentially do not feel pain.
Pain is meaningless to them, like color is meaningless to a colorblind man.
The implications of that are pretty terrifying to think about tbh
 
soymonkcel

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IMPORTANT INFORMATION

1. Introduction

View attachment 363735

Joan of Arc at the Coronation of Charles VII (1854), Jean Auguste Dominque Ingres.

Joan of Arc (1412-31) was an historical foid who lived during the Hundred Years’ War, a great conflict between France and England.

Born in the peaceful French village of Domrémy, Joan suffered from schizophrenic delusions since early childhood. At the age 17, she hallucinated that an evil spirit was instructing her to lead France’s army to victory over the English. She was so insistent about this that she was granted an audience with the royal court. Upon hearing her prophecy, the imbecilic King of France, Dauphin Charles VII, took her at her word and placed her in command of a battalion of soldiers.

Joan’s first military campaigns were successful. In 1429, Joan and her soldiers relieved the besieged French at the Siege of Orleans, earning her the title of “The Maid of Orleans.” In May, 1430, however, her fortunes changed dramatically and she was routed and captured by the English in Compiègne. After a short trial, she was sentenced to death by burning at for the crime of witchcraft.

Thousands of people witnessed Joan’s execution, and many accounts of her death survive to this day. As she burned at the stake, the following signs were observed:

1. Her muscles contracted and tensed up.
2. Her breasts became full and began to heave violently.
3. She cast her eyes up to heaven, and her expression was not one of pain, but something approaching spiritual ecstasy.
4, In the instant before she lost consciousness, Joan moaned out Jesus’s name three times, loud enough to be heard over the roar of the flames.
5. Joan’s vagina, in contrast to the dry kindling that burned around her, became lubricated and wet.

View attachment 363741

Individually, each of these signs do not point to a clear conclusion. But taken together, they indicate an undeniable certainty: as the flames enfolded and consumed her body, Joan of Arc was caught within the grips of a powerful orgasm.


2. Masochism

Masochism is defined as “the condition of experiencing recurring and intense sexual arousal in response to enduring moderate or extreme pain, suffering, or humiliation.” It’s described as an addiction-like tendency, with features resembling drug addiction: craving, intoxication, tolerance, and withdrawal.

Masochism is seen as aberrant in males and treated as a harmful psychological disorder.

Female masochism, on the other hand, does not suffer from the same stigma, given its ubiquity.



Confirming this, In Three Essays on the Theory of Sexuality (1924), Sigmund Freud described the three essential traits of femininity -- narcissism, passivity, and masochism. To Freud, pain was an inseparable part of the intensity of a woman’s sexual pleasure, “an expression of the feminine being nature.” He found in women a persistent need for punishment and humiliation, "which succeed [...] in binding erotically the destructive trends which have been diverted inwards."

There are numerous examples of masochism in females:

A. Women overwhelmingly prefer larger-than-average penises.

Here are some quotes from a VICE article:




The top selling dildos on the internet are eight to nine inches long. In the absence of a large cock, some women resort to bestiality with dogs and horses, animals with large cocks.

However, a penis of this size inflicts injuries and perforations on the vagina and causes lasting damage in the form of tears in the cervix, as well as dilation of the vaginal opening. Infections can occur, and there are several case reports of pelvic abscess and subsequent scarring due to insertion of large objects into the vagina.

B. Women love anal sex, despite the lack of an erogenous zone there.

Homosexual men also engage in anal sex. But keep in mind that gay men have erogenous zones deep within their ani known as prostate glands. Women lack this, and so in theory anal sex should be not pleasurable for them, and instead extremely painful. Nevertheless, women engage in sodomy for pastime.





Repeated anal sex (especially with the oversized penises women prefer) can harm the sphincter and rectum, leading to rectal prolapse and leakage/loose stools.

C. One reason women seek out and stay with attractive abusive men because they enjoy being beaten up.

Women seek out abusive (attractive) partners and stay with men who regularly beat them. In addition to psychological reasons, this is because the pain of getting physically assaulted turns them on. In fact, many women report having had the best sex of their lives immediately following such an “abusive episode.”

Studies on this phenomenon are suppressed and hidden by Google’s search algorithm.

D. Women engage in various paraphilias, including “knife play.”

Angelina Jolie reported that she could not reach orgasm during sex without being cut with a knife.


Here, the actress is referring to a variation of “knife play,” a common fetish among women in which a sharp knife is inserted carefully into the vagina, causing targeted lacerations in the walls of the cervix and sending waves of sexual pleasure surging through the woman’s body.

***

In each of the above examples, harmful stimuli that should be perceived as dysphoric are misinterpreted by the female brain as euphoric; women feel pain as pleasure, even when their bodies are placed at harm’s risk.

From this, we can conclude there is a maladaptive mechanism in the female brain whereby pain is transformed into its polar opposite pleasure. Psychological aspects to this masochism exist as well, but the basis of this pleasure is neurological.

3. Counterpoint

Despite this, many studies deny the existence of this innate masochism in females, some even claiming that women suffer more pain than men.

Here is one such study:

In this study, an equal number of men and women were exposed to painful electrical stimuli of controlled strength.
Pupillary dilation was measured in both groups, and each participant was asked to rate on a decile scale how much pain they felt.

The female group presented with more pupillary dilation than the male group, and rated their pain higher than the men did. From this, the researchers concluded that women felt more pain than men.

But there are two obvious flaws with this methodology.

First, measuring pupillary dilation to quantify perceived pain is unreliable, since pupils dilate in response to both pain and pleasure. The dilation itself does not signify that specifically pain or pleasure is being felt, only that one of the two are. Naturally, the researchers assumed that the pupils dilated due to pain, but logically, pleasure cannot be ruled out.

Pupils also dilate in response to any strong emotion.

The second, and more detrimental, flaw was in asking the subjects to rate their pain themselves.

As researchers at UCLA (Toomey, et al) pointed out:


Asking subjects to rate their own pain runs into the same problem as the studies that compare the number of sex partners between men and women. In that case, men exaggerated their true number, while women minimized theirs. Here, we can be sure that the opposite will be the case. Women will pretend to feel great pain because of hypochondria and victim complex, whereas men will attempt to appear masculine by deliberately minimizing the amount of pain they feel.

Because of these flaws in methodology, the only valid conclusion we can derive from this study is that, when it comes to injury, women complain more than men.

***

A second argument is that women feel more pain than men due to having more nerves.


This argument also fails to convince.

Since my thesis is that pain is felt as pleasure to women, the more nerves a person has, the more able she is to feel not only pain, but also the concomitant pleasure. Increased nerve density increases potentiality of pleasure as well as pain. And if during a given pain event the pleasure overcrowds the pain, that intermingled feeling can’t be said to be pain at all, but pleasure, mathematically speaking. In a linear sense, pain you want to repeat over and over again due to the pleasure you get from it can’t be called pain. It's similar to the pleasure of repeatedly scratching a mosquito bite or bearing down on an aching tooth.


4. The Perception of Pain as Pleasure (In Women)

[...] that peak of sensitivity where the scarlet and the white threads of ultimate pain and ultimate joy are woven together...
- Yukio Mishima, Runaway Horses

I. Men experience pain in the analytical regions of the brain, whereas women experience “pain” in the emotional regions.

In 2008, researchers at UCLA conducted a study focusing on gender differences in pain perception:


Here, researchers applied heat stimulations to the forearms of an equal number of male and female volunteers, while monitoring their brains using positron emission tomography (PET) scans.
The PET scans measured increases in blood flow and cerebral activation patterns during pain perception.

After analyzing the results, they concluded that “the cognitive, or analytic, region of the male brain lights up, while the female limbic system, the brain's emotional headquarters, springs into action.”


Specifically, males had a larger magnitude of opioid receptor activation in the following areas:
1. Anterior thalamus
2. Hypothalamus
3. Ventral basal ganglia

While females had far more opioid receptor activation in the limbic system, comprised of:
1. Amygdala
2. Hypocampus
3. Thalamus

As in the previous study, the researchers noted that “the females verbally perceived the 50°C heat stimulus as more intense compared with males.”

The authors speculated that, because pain causes an emotionally charged limbic response in women, that may be responsible for the greater
complaining from the women. In other words, women felt “offended” by this pain, as if it were a social faux pas, and reacted similarly to it as if they had been hurt psychologically, rather than physically.

The authors assimilated this difference with greater activation in the thalamus, anterior insula, and contralateral prefrontal cortex of females as evidenced by the PET scan. The difference found within the prefrontal cortex may be responsible for the affective, or psychological, differences seen between genders in pain perception.

Even a foid scientist agrees:




According to Graham, nociceptive pain sensed in the limbic system (as it is in women) cannot be differentiated from psychological pain when examined through current medical technology.

Thus, increased activity in the limbic system in response to physical pain stimuli does not necessarily indicate a felt non-psychological pain.
This further suggests that, for women (but not men), physical pain is almost indistinguishable from social, psychological pain, such as being excluded, offended, outraged, or sad.

A woman, unable to distinguish between emotional and physical pain except through first causes, evidently wouldn’t be able to understand the distinction, no more than a blind man can comprehend the concept of vision.


II. Pain response is “mu-dominant” in females, while it is “kappa-dominant” in males.

When a nerve ending detects a painful stimulus, it sends a signal to the central nervous system, where the body produces calming and pain-relieving hormones called endorphins.

Endorphins (contracted from endogenous morphine) are a opioid-like substance similar to fentanyl that reduces pain in response to painful stimuli. Endorphins are “caught” by different opioid receptors in various parts of the brain, and produce varying effects depending on the type of opioid receptor they are caught by.

There are three different types of opioid receptors: mu, kappa, and delta.
Mu and kappas are the two most significant receptors; delta receptors have minimal effect in alleviating nociceptive pain.
Binding sites for the three receptors overlap in many brain structures, but some structures exhibit higher expression of one receptor over the others.

Here are some “brain maps” that show where mu- and kappa-opioid receptors are found in the brain.

View attachment 363763



As you can see, mu-opioid receptors are more prevalent in the limbic system, whereas kappa-opioid receptors predominate in the cognitive centers of the brain.

Specifically:
Mu is the most expressed opioid receptor in the amygdala, thalamus, mesencephalon and some brain stem nuclei. (1)
In a few structures, only one receptor type is detected: mu binding sites only are detected in four thalamic nuclei (lateral geniculate thalamus, ventrolateral thalamus, ventromedial thalamus, and posterior thalamus), the sensory trigeminal nucleus (SNT) and nucleus ambiguus (Amb).

Kappa is the most represented receptor in the basal anterior forebrain, including the claustrum (Cl) and endopiriform cortex (En), olfactory tubercle (Tu), striatum (caudate putamen and nucleus accumbens), preoptic area (POA), hypothalamus, and pituitary.
Kappa binding sites only are found in seven brain regions that are part of the stress axis (Cl, paraventricular hypothalamus, arcuate nucleus, supraoptic nucleus, Me, CeA, and pituitary).

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482114/

A Yale study similarly found mu-opioid dominance in females and kappa-receptor dominance in males.

Males had significantly higher V T and thus a higher KOR (kappa opioid receptor) availability than women in multiple brain regions.

Mu-opioid dominance is also confirmed by better reaction from females to mu-opioid-specific drugs than men. Women required 40% less morphine (a mu-opioid-specific medicine) than men for post-operative, reardless of body weight or diffusion of the drug in the body.
Women also seem to get much greater pain relief from mixed-action opioid medications and experience greater pain relief with mu-specific opioids.
Based on these findings, researchers concluded that that mu-opioid receptor (MOR) binding density would be higher in females than in males.


In addition, the idea that males and females respond differently to opioids is not new, but until recently the difference was believed to be limited to potency, with clinical studies showing that women require less morphine for post-operative pain than men.
(4) Research by Craft found that women use 40% less opioid-based medicine than men for postoperative pain.10 This finding was confirmed by Miaskowski et al in an analysis of 18 studies of postoperative opioid use.
Several studies of pain after oral surgery revealed that women get much greater pain relief from mixed-action opioid medications (eg, pentazocine, nalbuphine, butorphanol).12 More recently, a meta-analysis of this literature confirmed that women seem to experience greater pain relief with opioids.
In their study, the researchers also discovered that female rats received significantly more pain relief when mu opioid was injected into the vlPAG than male rats, a fact that was not attributable to body weight or diffusion of the drug in the body.
***
Moreover, men are more likely than women to engage in substance abuse (Lynch et al. 2002), while women become addicted to opiates more quickly following first use (Lex 1991; Roth et al. 2004). Similarly, female rats acquired heroin self-administration more quickly than their male counterparts, and subsequently, self-administered larger amounts of the drug (Lynch and Carroll 1999; Cicero et al. 2003). It is plausible that sex differences in MOR activation underlie sex differences in these behaviors. In support, PET scan studies revealed higher MOR binding in several brain regions of women compared to men (Zubieta et al. 1999). Likewise, higher MOR binding density was found in several brain regions in female rats compared to males, although these rats were gonadectomized (Vathy et al. 2003). However, it remains unknown whether sex differences are present in the intact rat brain and whether these sex differences emerge early in development. Therefore, our second aim was to compare MOR binding density between intact male and female rats at both juvenile and adult ages. Based on these previous findings in humans and gonadectomized adult rats (Zubieta et al. 1999; Vathy et al. 2003), we hypothesized that MOR binding density would be higher in females than in males.

III. Mu are the rewarding receptors, while kappa are the punishing receptors.

Mu and kappa receptors both serve a role in mediating nociceptive pain, but do so in different ways. To put it simply, mu-opioid receptors “reward” pain, whereas kappa receptors “punish” it.

The functional response of mu- and kappa-opioid receptors can be replicated through the administration of mu-specific or kappa-specific drugs. The pain response of opioid receptors can be emulated to a greater or lesser extent by administering these drugs and observing their effects.
In other words, the effects caused by theses receptor-specific agonists are the same (differering only in degree) as the “natural” response to pain caused by non-artificial means of activation (i.e. actual pain stimuli, rather than induced activation).


A. Mu Receptors

The areas in which mu-opioid receptors are most prevalent (the limbic system, the primary regions in which females register pain) are known informally as “hedonistic hotspots.” These areas of the brain play a large role in the reinforcement of pleasure. Overactivation of this area are drug addiction, food addiction, etc.
These receptors contribute to the reinforcing properties of most drugs of abuse.
Stimulation of mu opioid receptors generates an increase in both “liking” and “wanting” for reward.
Thus, mu-opioid receptors induce relaxation, trust, satisfaction and have a strong analgesic effect.

Morphine is a powerful pain relieving drug that produces euphoria. It is mu-opioid specific, meaning it acts on and targets the mu-opioid receptors. Other mu-specific drugs include heroin and fentanyl. Most opioid drugs of abuse fall under this category.
The effects of morphine include euphoria, mood lift, relaxation, and analgesia.


Relevant to drug intake, genetic data demonstrate that mu receptors contribute to the reinforcing properties of most drugs of abuse, [...]
The opioid system, which mediates hedonic evaluation of natural rewards, represents another key substrate for the deleterious effects of drugs of abuse. Indeed, the reinforcing properties of many abused drugs depend on the activation of mu opioid receptors
which thus may be a potential molecular gateway to drug addiction (72).
Conversely, mu and delta antagonists [medications which inhibit the effect of these receptors] suppress the positive reinforcing properties of natural rewards and opiate or nonopioid drugs, whereas kappa receptors induce dysphoria and counteract mu receptors in regulating hedonic homeostasis. (2)
SOURCE: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482114/

B. Kappa Receptors

Kappa is generally known to be a dysphoric, aversive receptor in terms of its pain-mediating effects.

While systemic mu agonists (morphine, heroin, etc) produce positive reinforcement, kappa agonists induce aversion, hallucinations, and malaise, producing anxiety, fear, and depression.
Furthermore, activation of kappa receptors counteract the reward processes of the mu-receptors, and in male models, increases psychological discomfort associated with pain.

Because of these dysphoric effects, no kappa-specific drug is in wide use today, either as anaesthesia or recreationally. Mixed-action opioids, however, such as nalbuphine, have been used on women to some success, although they are ineffective in men (See Section IV).

Kappa receptors are the “punishing” receptors.
It is believed that kappa-opioid receptors exist to produce avoidance behaviors in response to pain, causing extreme negative feelings to be associated with the source of the pain, so that the brain can learn to avoid similar sources of pain in the future.

Pharmacological studies have long shown that kappa receptor activation is aversive in animal models.
Globally systemic mu agonists produce positive reinforcement, whereas kappa agonists induce aversion, hallucinations, and malaise.
Kappa receptors also counteract reward processes under stressful conditions.

Traditionally, kappa-opioids have been dismissed as ineffective analgesics in humans.
Nalbuphine, which is often used to anesthetize women during childbirth, does little to mitigate pain in men.

Kappa receptors induce dysphoria and counteract mu receptors in regulating hedonic homeostasis. (2)
SOURCE: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482114/

KOR agonists produce signs of anxiety, fear, and depression in laboratory animals and humans, findings that have led to the hypothesis that drug withdrawal-induced DYN release is instrumental in negative reinforcement processes that drive addiction. However, these studies were almost exclusively conducted in males.

***

In short, MOR (mu-opioid receptors) produce a euphoric effect in response to pain, similar to that of fentanyl, heroin, or morphine.
KOR (kappa-opioid receptors), however, produce a dysphoric effect, causes psychological discomfort, anxiety, fear, and depression.

IV. Kappa receptors work synergistically with mu receptors in females, increasing the “rewarding” effect. In contrast, the two receptors work at cross purposes in males; kappa decreases the effect of mu receptors in men, thereby increasing the “punishing” effect.

In Section III, it has been established that kappa receptors are punishing and dysphoric. New studies have suggested, however, that the negative effects of KOR activation seems to only be present in males. In females, kappa receptor activation appears to have a synergistic effect with mu-opioid receptors, making the “rewarding” aspects of it more powerful.

Because kappa-opioids had mostly been tested on male subjects, on whom kappa activation results in dysophoria and great mental distress, medical professionals traditionally have dismissed kappa-opioids as viable analgesics in humans.

However, UCSF scientists recently performed a study about the analgesic effects of kappa agonists, this time on human female subjects.
They undertook this after a previous study discovered that kappa-opioids brought pain relief to female rats but not male rats.

They found that in women, a drug made up of a strong concentration of kappa-opioid has a strong and lasting analgesic effect.
In contrast, in men, the low dose actually increased pain; as the dose was increased, the heightened pain disappeared and a weak, short-lived analgesic effect set in.

In their previous study on rats, the Fields team showed that treating the vlPAG neurons of male rats with a mu opioid brought about pain relief, but that subsequently adding kappa-opioid into the RVM markedly decreased the mu opioid’s analgesic effect.
In males, KOR worked to sabotage MOR in a sense, and decreased the rewards of mu.

However, Treating the vlPAG neurons of female rats with a mu opioid brought on the expected pain relief, but subsequently adding kappa-opioid into the RVM increased the mu opioid’s analgesic effect.

Traditionally, kappa-opioids have been dismissed as ineffective analgesics in humans.
While the majority of sex difference findings related to KOR are from studies of the analgesic effects of kappa agonists, there is also emerging evidence of KOR-related sex differences in addictive and affective states [6].
This led them to reexamine the posibility of using kappa-opioids as analgesics, only in human females.
Researchers led by UCSF scientists are reporting that an experimental pain drug known as a kappa-opioid brings pain relief to female rats but not males, a finding that adds weight to a recent UCSF clinical finding, and highlights, they say, the need to evaluate drugs by gender.
Fields’ finding-that specific brain regions in male and female rats have opposite reactions to kappa-opioids, supporting clinical studies at UCSF that indicate kappa-opioids are more effective in women for clinically significant pain.
A clinical study led by UCSF professor Jon Levine, MD, PhD showed that, in women, a drug made up of a strong concentration of kappa-opioid has a strong and lasting analgesic effect.
In contrast, in men, the low dose actually increased pain; as the dose was increased, the heightened pain disappeared and a weak, short-lived analgesic effect set in.
The discovery, he says, demonstrates a clear biological difference in the way women and men respond to kappa-opioids.
Three years ago, the Fields team showed that treating the vlPAG neurons of male rats with a mu opioid brought about pain relief, but that subsequently adding kappa-opioid into the RVM markedly decreased the mu opioid’s analgesic effect.
Treating the vlPAG neurons of female rats with a mu opioid brought on the expected pain relief, but subsequently adding kappa-opioid into the RVM increased the mu opioid’s analgesic effect.
“In males, kappa-opioid is somehow inhibiting the actions of mu-opioid,” says Fields.
Kappa receptors are acting on opposite types of neurons in males and females. In males, kappas may be inhibiting the so-called “off” nerve cells in the RVM that normally tell the spinal cord to shut off pain signals. In females, kappa-opioids actually excite the off neurons, which would relieve pain.


In men, however:
The functionality of kappa- and delta-opioid receptors, might be less associated with relaxation and analgesic effects as kappa-OR often suppress activation of mu-opioid receptors, and delta-OR differ from mu-OR in its interaction with agonists and antagonists.

What these studies show is that mu- and kappa-opioid receptors work at cross-purposes in males, decreasing the rewarding effects of mu receptors.
However, the two receptors work synergistically in females; kappa activation increases the rewarding effects of mu receptors.

V. Estrogen is a natural painkiller that modulates opioid receptors to be more effective.

Estrogen is present in women at a level that is 10 to 15 times higher than the level present in men.

In 2011, researchers (Stenning et al) discovered that estrogen can modulate the density of opioid receptors.

Estrogen have also been found to induce mu-opioid receptor activation within the preoptic nucleus and posterodorsal medial amygdaloid nucleus.

High densities of estrogen receptors functionally related to endorphin receptors have been found within the hypothalamus, one of the primary sites of MOR. [mu-opioid receptors]

In addition, research on sex hormones indicates there is improved mu receptor binding in some brain regions in women after they receive estrogen, as measured by PET scans.
One of the conclusions forwarded from this research is that a decrease in estrogen would increase sensitivity to pain. Conversely, an increase in estrogen would promote analgesic effect by stimulating a bolus of pain-inhibiting transmitters.

The effects of estrogen modulation of pain receptors is further confirmed in a study by Dr. Kern Olson.
According to him:
Girls and boys react to pain in a similar fashion before puberty but differently after puberty; these differences, however, decrease as levels of sex hormones decrease as people age. (i.e., after menopause, when estrogen levels in women plummet)


Aside from their function in reproduction, sex hormones and their receptors that are widely distributed throughout the central nervous system have
demonstrated modulatory effects on the central opioid system to responses in pain.

Estrogen have also been found to induce mu-opioid receptor activation within the preoptic nucleus and posterodorsal medial amygdaloid nucleus.

High densities of estrogen receptors functionally related to endorphin receptors have been found within the hypothalamus, an area
with a high density of neuroendocrine and centrally projecting neurons.
(Toomey et al)
29 This effect can be blocked by the mu-opioid antagonist naltrexone,
29 which further demonstrates these hormoneopioid receptor interrelationships.
In addition, research on sex hormones indicates there is improved mu receptor binding in some brain regions in women after they receive estrogen, as measured by PET scans.
One of the conclusions forwarded from this research is that a decrease in estrogen would increase sensitivity to pain. Conversely, an increase in estrogen would promote analgesic effect by stimulating a bolus of pain-inhibiting transmitters.22



VI. Opioid receptor activation is anti-sexual in men, pro-sexual in women.

According to the same study above:


On a study on rats, an injection of mu-specific opioid drugs into the brains of male rats were seen to suppress male gonadal function. In other words, the rats were unable to maintain an erection after being administered these drugs, and mating behaviors decreased in response.

However, in female rats, administration of mu-specific drugs did not correlate with symptoms of sexual dysfunction.
On the contrary, when mu-opioids were administrated to female rats only in a group, unpaced mating increased. This nymphomania was increased the closer the rats got to estrus, corresponding with higher levels of estrogen. This was associated to higher rates of mu activation, which suggests a certain threshold of pain must be reached before sexual arousal happens.
This suggests that the pro-sexual effect of MOR activation on females will increase when estrogen levels are higher, such as during estrus, certain phases of the menstrual cycle, and the later terms of pregnancy.

The researchers reported that with lower levels of estrogen, progesterone was pronociceptive.
Thresholds were decreased, and pain intensities increased during the midluteal phase when progesterone levels were relatively higher than estrogen levels.

[19] This system is also thought to be important in mediating complex social behaviors involved in the formation of stable, emotionally committed relationships. Social attachment was demonstrated to be mediated by the opioid system through experiments administering morphine and naltrexone, an opioid agonist and antagonist, to juvenile guinea pigs. The agonist decreased the preference of the juvenile to be near the mother and reduced distress vocalization whereas the antagonist had the opposite effects. Experiments were corroborated in dogs, chicks, and rats confirming the evolutionary importance of opioid signaling in these behaviors.
[18] Researchers have also found that systemic naltrexone treatment of female prairie voles during initial exposure to a male reduced subsequent mating bouts and nonsexual socialization with this familiar partner, when a choice test including a novel male was performed afterwards. This points to a role for opioid receptors in mating behaviors.

Stenning et al studied the pain response across the menstrual cycle phases using a cold pressure test. In this study, a demonstration of variations in pain perception that correlate with the fluctuating concentration ratios of estrogen and progesteronewas conducted. The researchers reported that with lower levels of estrogen, progesterone was pronociceptive.
thresholds were decreased, and pain intensities increased during the midluteal phase when progesterone levels were relatively higher than estrogen levels.

Briefly, opioid receptor agonists injected directly into the MPOA inhibited or delayed masculine copulatory activity in rats. Indeed, when injected into this structure, opioid agonists markedly impaired penile erection
Opioids frequently cause low FT levels in men, but there is no relationship between abnormal hormone levels and symptoms of sexual dysfunction. Therefore, all men should be screened for low FT levels. Women on opioids had lower FT levels, but this did not correlate with sexual dysfunction symptoms.

This pro-sexual phenomenon can be observed in human females as well. Estrogen serves to increase the feelings of sexual arousal derived from pain.

This effect can be seen in the “birthgasm.” During pregnancy, the estrogen levels in a women increase the closer she gets to giving birth. This effect is seen during pregnancy and may account for pregnancy-induced increases in tolerance to nociception. This may have evolved so that a woman could better tolerate the “pain” of childbirth. As a result, a woman’s estrogen levels are necessarily highest just before and during the act of giving birth. Estrogen and MOR activation working in tandem have often resulted in women having orgasms during childbirth:

When a woman feels the contractions of an orgasm and/or extreme moments of pleasure right at the moment of delivering her baby, this may be called an “orgasmic birth.” You may feel tremendous pressure and sensation in the vagina as your baby's birth approaches, then a powerful, pleasurable release that's both physical and orgasmic.

This phenomenon is common enough that the term of “birthgasm” was coined.

5. Acupuncture

Acupuncture was a saving grace. It helps more than anything else I tried.
- Molly Qerim, a foid

***

Acupuncture is a form of alternate medicine in which thin needles are inserted into the body. The practice of acupuncture is considered a pseudoscience because the theories and practices of traditional Chinese medicine -- based on the concepts of qu, meridians, and acupuncture points, life force energy -- are not amenable to modern scientific knowledge, and it has been characterized as quackery.
Many scientific reviews have found that acupuncture is ineffective for a wide range of conditions.

Some research results suggest that it can alleviate some forms of pain, though the majority of research suggests that its apparent effects are not caused by the treatment itself. Many acupunctures attribute pain relief to the release of endorphins when needles penetrate.



In other words, there is a prevailing theory that the way acupuncture “works” is by causing pain that causes the body to go into pain control overdrive, releasing endorphins and creating a state of well-being.

Unsurprisingly, the great majority of proponents of acupuncture are female. By some estimates, the ratio of women to men who use acupuncture regularly is 5 to 1. (This especially applies to East Asian women, who are on average more masochistic and exogamic than women of other races.) Discounting the placebo effect, the logical explanation is that acupuncture works for women, but not men.


To see why this is, let’s examine the differences of male and female brains’ reactions in response to acupuncture.

In males:
The needle is inserted.
Pain is sensed by the nerves.
A small number of rewarding mu receptors activate, and a large number of punishing kappa receptors activate.
Mu receptors try to “reward” for the pain. However, the kappa receptors lessen this effect.
Male feels pain and aversion. He begins to associate acupuncture with negative feelings of dysphoria.
The man’s sexual desire decreases, and erection becomes impossible.

In females:
The needle is inserted.
Pain is sensed by the nerves.
A large number of rewarding mu receptors activate, and a small number of synergistically rewarding kappa receptors activate.
Mu rewards the woman for the pain. Kappa helps this effect, transforming pain into pleasure.
Estrogen modulates the pain response, causing sexual arousal.
Female feels euphoria and sexual arousal. She begins to associate acupuncture with positive feelings of euphoria.
The woman’s sexual desire increases; her desire for unpaced mating goes up.

It’s not difficult to see, then, why women are the primary consumers of acupuncture.

***

A famous example of acupuncture working as advertised proves my point further.

In the early 20th century, surgeons performed open heart surgery on a 15-year-old girl in China without using anesthesia. The only measures taken to alleviate the pain of the surgery was acupuncture. Nevertheless, it is said that girl remained calm and immobile during the operation, which was a great success. To this day, this is held up as one of the primary pieces evidence of evidence in support of the efficacy of acupuncture.

However, notice that it was a girl who received the surgery, and not a boy. A male would scarcely have been able to endure the pain of the operation. However, it would have been no difficulty at all for a female.

View attachment 363768


Open heart surgery under acupuncture anaesthesia is depicted on this 8 cent Chinese stamp issued in 1975 as part of a set of four stamps to commemorate the successful integration of traditional Chinese medicine and modern Western medicine in the treatment of various diseases.

The four Chinese characters at right lower corner of the stamp stand for acupuncture anaesthesia. The other three stamps in the set feature such surgical feats as replantation of severed limbs, application of small soft splints for fractures, and cataract surgery.

The patient in this stamp was a 15 year old girl with congenital ventricular septal defect. The Chinese made disc oxygenator for total cardiopulmonary bypass can be seen on the right. The anesthetist who performed the acupuncture-two fine needles inserted in both wrists and a further two in the anterior chest wall at both subclavicular areas-was at the patient's head; he was a practitioner of Chinese traditional medicine. The surgeon on the patient's left was Professor Yi-shan Wang, my schoolmate in St John's University School of Medicine, Shanghhai, China, and the surgeon on the patient's right was Dr Chun-xiu Yeh, my classmate in the same school.


6. Conclusion

Proposed Changes to Society:

1. Medication.
Opioids and anesthetics are inherently dangerous to administer to women, since there is a greater chance of overdose and addiction. (See III.A)
As a result, it would be beneficial for their safety if anesthetics were not administered during female patients’ surgeries.
Anesthesia can be replaced with acupuncture for female patients, which, as shown above (5), has comparable efficacy and far less risk.
This will also increase supply and decrease demand of anesthesia medication, leading to a decrease in the cost of expensive anesthesia procedures.


2. Abortion.
Many current proponents of abortion justify the legality of early-term abortion by the logic that the baby does not yet feel pain.
Following this logic, it would seem that crimes are more serious the more pain is caused.
But women essentially feel no physical pain, as shown above.
To maintain legal consistency, it follows that either abortion must be classed as murder, or crimes that cause bodily injury (battery and domestic assault) to women should not be punished as harshly as those which cause bodily injury to men.

3. Scientific Studies.
German scientists and physicians made great medical advances in the 1940s, due to their progressive genetic research and innovative surgical experimentation, particularly in the area of twins. This was a time of medical enlightenment, and many of the concepts they discovered are still used today. Various legislative considerations, however, prevent us from conducting similar studies today.
However, since our knowledge of the nature of human suffering was then incomplete and now we are more informed, some of these restrictions can now be loosened on experimentation on female subjects.

@ShadowTheEdgehog
@Mainländer
Deluxe quality thread. Brilliant and gigabased. Hasn't it been moved to the must read section already?

Now everything makes so much fucking sense. I remember the days I was in a group of discussion of non-monogamy years ago (in my feminist ally days, ugh). There was a couple of gals or three that where very into BDSM (because this is another thing mostly women are into, not men), and I remember asking them "Why do you like it so much?", and they all agreed that "The combination of pleasure and pain felt good", and I never understood such an answer... until now. I only knew that pain really cause a released endorphins that bind to MORs to mitigate the pain, but I thought that should extend to men, so I felt something was a bit off. Now I see things clearly.
I think @soymonkcel would like the part about Kappa versus Mu receptors.
You guessed right, my fren.
Because of these dysphoric effects, no kappa-specific drug is in wide use today, either as anaesthesia or recreationally.
Salvia divinorum. It's a KOR agonist hallucinogen that is "fun" in its own way. That drug is very interesting because in my time experimenting with it, I learned a lot about KOR activity not only from a scientific perspective, but from a subjective one, and this post has given me more insights and I have theories popping up in my head all at once.

As it's seen in your OP, women have a synergistic effect of MOR agonism with KOR agonism, while the effects of KOR agonism in men inhibits the euphoric effect of MOR agonism. The other difference is not only the distribution of those receptors, but the amount: men have more. So far so good. But I think there is a catch here. I have to look for studies I red once mentioningg that low activation of KOR can have that synergistic effect (and also cause dopamine receptors upregulation in the nucleus accumbens, I don't remember the details) and, upon trespassing a certain threshold of activation, instead of synergistic it becomes pro-inhibitory of MOR neurons. If women have less KORs, then the activation of those neurons would be lower, thus having a higher probability of experiencing that synergistic effect inmost cases. But, interestingly enough, I think men can have that synergistic effect too if the dose of the KOR agonist is low enough: when I did Salvia divinorum in high doses, it really felt dysphoric (everything was odd/alien/warped and I was anxious, like If I just simply ingested a paralyzing poison), but when I did it in low doses, it felt euphoric. I once was there sitting in my backyard, looking at the sky under the effect of chewing only 3-5 leaves and saying "Whoah, dude. Look at the sky. Isn't it impressive?" And my bro was playing smash bros and I remember looking at the characters and listening to the music and everything about them looked like 5 times cooler. It totally enhanced my experience every time. So again, maybe with the right dosage, we can elicit the same kappa-euphoric response in men, but definitely not through pain.
Might go in as record longest OP posted on this forum tbh
Almost. @Dalek.Skaro has the record. But, does it matter? This must go to the must read section.
 
epillepsy

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The implications of that are pretty terrifying to think about tbh
I should point out that after menopause, foids have very low estrogen levels.
Without estrogen modulating their mu-opioid receptors to be more rewarding and sexually arousing, their ability to feel pain increases (though not to the level of a man's pain).
If they've never felt any sort of real pain throughout their life and suddenly they are feeling moderate pain from arthritis, they will think that is agony comparatively, though it's nothing to what a man would feel.
That's why some women rope after getting arthritis in old age, which is when they feel the first discomfort in their bodies.

Salvia divinorum. It's a KOR agonist hallucinogen that is "fun" in its own way. That drug is very interesting because in my time experimenting with it, I learned a lot about KOR activity not only from a scientific perspective, but from a subjective one, and this post has given me more insights and I have theories popping up in my head all at once.
I've heard bad things about salvia and have been afraid to try it.
 
soymonkcel

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I've heard bad things about salvia and have been afraid to try it.
As I said, as long as you do a chewed low dose (opposed to a smoked/vaped high dose) and you don't mix it with caffeine, alcohol or other drugs, you should be fine. It lasts only 10-30 min.
 
Transcended Trucel

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God tier IQ thread. Matches up with alot of stuff I have seen in real life. it's no wonder foids stay with abusive boyfriends, abuse gives them pleasure.

Number of particles in the Universe IQ.

Foids get turned ON by pain, that is why they get attracted to violent and Dark triad Chads so much.

Even a coalburner got so many pairs of mudshark sunglasses, she will still stick to the Tyrone who gave her.
This explains a lot of what I've observed in life. Fantastic thread.
 
Lv99_BixNood

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Well, I finished reading the thread, I had not read something so well constructed for a long time, and as a bonus your post gives a new paradigm in the way of seeing the human being and especially women. Your post reminded me of this:


Great minds think the same.
This guy's doujins are an elaborate dissertation on the female psyche.
 
Gymcelled

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I archived the articles just in case

Do men and women feel pain differently?

Course Update for Nurse Anesthetists Gender Differences in Pain : Does X = Y ?

Ouch! Why Women Feel More Pain

Gender differences in pain ratings and pupil reactions to painful pressure stimuli

Angelina Jolie reveals her dark sexual exploits

This is the best way to give a woman an orgasm, apparently

The Riddle of the Sphincter

We Spoke to Size Queens About Why They Prefer Big Dicks

Pain drug reveals what most already know - men's and women's brains are simply different

Reward Processing by the Opioid System in the Brain

Reward Processing by the Opioid System in the Brain

Gender and the Pain Experience

Gender Differences In Brain Response To Pain

Gender Differences in Traditional Chinese Medicine Use among Adults in Taiwan
Based

Also highest iq i've seen in months. Maybe this year
 
Grothendieck

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My nigga literally wrote a research paper on this shit.
Such a good thread. Best one I've read here. Should be in Must Read Section.
 
Darkenzo

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Well yeah, what did you think S&M was all about?
 
EdgyPatrician

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Very enlightening read. It's not really surprising, but good to see the scientific evidence.
I can't satisfy this desire in foids. I'm not an aggressive, dominant person and never will be. It's absolutely over.

This is as high IQ as it gets.
You should check this out



" It was not the first time I had actually had sex but it was the first orgasm I had experienced."
JFL at all the NPCs trying to blame the orgasm on the physical stimulation. She has had sex before and didn't orgasm once. That should ring a bell, but it can't be, what must not be.
 
epillepsy

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Well yeah, what did you think S&M was all about?
It's common knowledge that all women are masochists but most say it's 100% due to psychology, rather than neurology, when in fact it's a mix of both, leaning more heavily toward flaws in foids' brain processes.

Do you agree with my conclusion that since women can't feel pain and they use the argument that "clumps of cells" cannot feel pain in order to say that abortion should be legal that abortion should be banned and persecuted as murder?
 
karmicrevolt

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This is fuckin phenomenal. This should be required reading everywhere.

What do you think this means for "rape culture"?
 
Grothendieck

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This thread confirms the big dick theory.
Average-above average is not enough.

@Personalityinkwell
 
epillepsy

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This is fuckin phenomenal. This should be required reading everywhere.

What do you think this means for "rape culture"?
aren't 98.75% of rape accusations false?
rape culture has a false premise -- that rape is being normalized -- since rape is seen to be the worst crime possible, even worse than murder, treason, or killing your own helpless infant baby. it's not normalized at all.

i don't know what it means for rape culture but i think that people in general shouldn't feel pity or sadness for women in "pain."
we have to learn to look past the outer signs of pains which foids have learned to mimic and not make rash decisions or laws based on the feelings of women, just like we shouldn't ban certain foods or do free-range farming so that cows are happier, which just makes beef more expensive.
 
karmicrevolt

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aren't 98.75% of rape accusations false?
rape culture has a false premise -- that rape is being normalized -- since rape is seen to be the worst crime possible, even worse than murder, treason, or killing your own helpless infant baby. it's not normalized at all.

i don't know what it means for rape culture but i think that people in general shouldn't feel pity or sadness for women in "pain."
we have to learn to look past the outer signs of pains which foids have learned to mimic and not make rash decisions or laws based on the feelings of women, just like we shouldn't ban certain foods or do free-range farming so that cows are happier, which just makes beef more expensive.
Agreed on all fronts. If only soyciety was able to look at pure facts like you are and come to this same conclusion -- we shouldn't have to pay more money so an unfeeling animal we're going to eat anyways is happier, so we shouldn't have to make laws so a lying foid claiming to feel pain (which she scientifically can't) is happier, right?
 
epillepsy

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Agreed on all fronts. If only soyciety was able to look at pure facts like you are and come to this same conclusion -- we shouldn't have to pay more money so an unfeeling animal we're going to eat anyways is happier, so we shouldn't have to make laws so a lying foid claiming to feel pain (which she scientifically can't) is happier, right?
i'm sensing some sarcasm on your part.
am i correct?
 
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karmicrevolt

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i'm sensing some sarcasm on your part.
am i correct?
Oh fuck, not at all, genuinely. Tone is just hell online and I'm really bad at communicating... It's one of the reasons I'm here, honestly. Sorry about that.
 
epillepsy

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Oh fuck, not at all, genuinely. Tone is just hell online and I'm really bad at communicating... It's one of the reasons I'm here, honestly. Sorry about that.
np
yeah, animal activism and female activism go hand in hand and both have gotten too extreme based on the false equivalency men make between their own suffering and the suffering of foids and animals, which aren't equal.
 
Darkenzo

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Do you agree with my conclusion that since women can't feel pain and they use the argument that "clumps of cells" cannot feel pain in order to say that abortion should be legal that abortion should be banned and persecuted as murder?
I don't know about tbh, it's like saying this is a cake.



And this is a baby.

1604219968861.jpeg


It would be easier if women just use contraception though,I don't know what's wrong with them.
 
epillepsy

epillepsy

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I don't know about tbh, it's like saying this is a cake.



And this is a baby.

View attachment 364711

It would be easier if women just use contraception though,I don't know what's wrong with them.
I see you're going straight to the standard arguments.

forget it then. you're right.
 
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Adrian Shephard

Adrian Shephard

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Holy crap, amazing read, gj OP

Also, daily reminder that people who biologically see pain as pleasure have voting rights. FOIDS, THE NATURES MASOCHISTS DECIDE ABOUT THE FUTURE OF NOT ONLY THEMSELVES BUT ENTIRE COMMUNE ASWELL. Are we suprised that rights of the criminals are so protected as they are in western countries right now? :feelsclown::feelsclown::feelsclown:
 
BurakuminBibba

BurakuminBibba

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God tier IQ thread. Matches up with alot of stuff I have seen in real life. it's no wonder foids stay with abusive boyfriends, abuse gives them pleasure.
tbh this is very true, i know so many women in abusive relationships and they love it. crazy High IQ thread