Theory Autism & Schizophrenia: Genetic Associations

[Intellau_Celistic]

 

[trognarukk]

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On a scale from 1-10 how many thoughts go throgh your mind right now?

 

[Intellau_Celistic]

https://journals.sagepub.com/doi/full/10.1177/03000605221138492

 

[Bianor]

On a scale from 1-10 how many thoughts go throgh your mind right now?

How does that work

 

[Intellau_Celistic]

 

[Intellau_Celistic]

Archived nicely.

 

[Intellau_Celistic]

Archived.

 

[Intellau_Celistic]

How does that work

It isn't clear-cut.

 

[Intellau_Celistic]

Archived nicely.

 

[Intellau_Celistic]

(Maternal)

 

[kay']

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(Maternal)

bro

 

[Intellau_Celistic]

The color scheme implies systemization.

C1:

The hypersystemizing theory of autism suggests that autistic individuals, on average, have superior attention to detail, and a stronger drive to systemize. Systemizing involves identifying input-operation-output relationships. Here, we report the results of genome-wide association studies (GWAS) of systemizing measured using the Systemizing Quotient - Revised in n = 51,564 individuals. We identify three genome-wide significant loci: Two of these were significant in the non-stratified GWAS: rs4146336 on chromosome 3 (P = 2.58×10−8) and rs1559586 on chromosome 18 (P = 4.78×10−8). In addition, we also identified a significant locus in the males-only GWAS (rs8005092 on chromosome 14, P = 3.74×10−8). We find that 12%± 1.2 of the variance in systemizing is captured by SNPs (P=1.2×10−20). We identify a positive genetic correlation between autism and systemizing (rg = 0.26±0.06; P = 3.35×10−5), which is independent of genetic contribution to educational attainment. We further demonstrate that genetic risk for autism from systemizing is genetically distinct from genetic risk emerging from social autistic traits, suggesting distinct shared genetics between autism and social and non-social traits. Our results highlight the importance of considering both social and non-social autistic traits in elucidating the genetic architecture of autism.

Systemizing is genetically correlated with autism and is genetically distinct from social autistic traits

The hypersystemizing theory of autism suggests that autistic individuals, on average, have superior attention to detail, and a stronger drive to systemize. Systemizing involves identifying input-operation-output relationships. Here, we report the results of genome-wide association studies (GWAS)...

www.biorxiv.org

We'll review it again in a few days.

 

[kay']

The color scheme implies systemization.

C1:

Systemizing is genetically correlated with autism and is genetically distinct from social autistic traits

The hypersystemizing theory of autism suggests that autistic individuals, on average, have superior attention to detail, and a stronger drive to systemize. Systemizing involves identifying input-operation-output relationships. Here, we report the results of genome-wide association studies (GWAS)...

www.biorxiv.org

We'll review it again in a few days.

Dnr

 

[Intellau_Celistic]

We review another form of possible implied systemizing.

C2:

In 2003, we proposed the hypersystemizing theory of autism. The theory proposes that the human mind possesses a systemizing mechanism (SM) that helps identify lawful regularities (often causal) that govern the input-operation-output workings of a system. The SM can be tuned to different levels, from low to high, with a normal distribution of individual differences in how strongly people search for such input-operation-out-put regularities in any data that is systemizable. Evidence suggests that people with autism are on average hypersystemizers, scoring higher than average on the systemizing quotient and on performance tests of systemizing. In this article, we consider the neural basis behind the SM, since there has been little consideration of the brain basis of systemizing. Finally, we discuss directions for future work in this field.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789212/

 

[Intellau_Celistic]

Another systemizing review is offered for the thread.

C3:

 

[Intellau_Celistic]

 

[IronsideCel]

7-11.

 

[IronsideCel]

Bitch.