Is it possible to escape depression as friendless incel ?
It depends on what you mean by derpression.
[1] Depression the illness, a.k.a. "Major Depressive Disorder"? I believe so: exercise, eat well, sleep well, find good copes and (maybe) try going to thERapy and taking some jewpills (bonus if they nullify your libido).
[2] Depression the emotion, the natural result of contemplating the infinite depth of the abyss of existential dread while disrobed of the bluepill gown you've been wearing all your life just to realize you're a genetic dead-end, a man exiled from the human race, destined to be a no more than a leaf in the tree of life, waiting the season for you to writhe, dry out and fall down towards the eternal oblivion without having produced branches, flowers, fruits but whose only purpose is to have had the sap drained from you once you exercised your usefulness, if any?
Unlikely, buddy boyo.
Some claim to have found the "whitepill", or maybe some form of transcendence -- becoming a catholic monk, or a buddhist, to attain nirvana, for instance. And from that path they claim to have leraned to accept their existence, and are able to rid themselves from the attachment to this life, this world, these desires (sex, companionship, social validation etc.). I don't know if this works, I haven't tried buddhism.